Preclinical data in melanoma mouse xenografts and osteosarcoma cells, showed that dinaciclib induces apoptosis, increases Bax and Bim in mitochondria, and decease antiapoptotic factors, such as Mcl-1, Bcl-2, Bcl-xL and XIAP, as well as phosphorylation of Ser2 of RNA Pol II. The gene discussed is MCL1; the disease is melanoma.