Dvl2 is sufficient for mouse neural tube closure, as Dvl1/Dvl3 null embryos do not display NTDs while Dvl1/Dvl2 or Dvl2/Dvl3 null animals exhibit craniorachischisis (Wang, J. et al., 2006; Etheridge et al., 2008). The gene discussed is DVL3; the disease is craniorachischisis.