CHI3L1 and breast cancer: Chi3L1 has also been found to promote colorectal cancer development via the induction of MAPK signaling leading to cellular proliferation and angiogenesis (Kawada et al. 2012).Through induction of several inflammatory factors, Chi3L1 has been proposed to enhance inflammation mediated metastasis of breast cancer in xenografted tumor bearing mice (Libreros et al. 2012).