Moreover, among the differentially expressed genes, a significant number has been described to be transcriptional direct targets of Pax5. One of the top-ranking up-regulated genes was the Src kinase Lck, a Pax5 repressed target gene, which has a potential role in a wide range of hematological malignancies [12–16] and interestingly, acts as an inducer of Stat5 hyper-phosphorylation in Ba/F3 pro-B cells [17]. Here, PAX5 is linked to hematologic disorder.