Docetaxel-resistant PCa cells possess an increased number of cells with an undifferentiated phenotype due to the lack of low molecular weight cytokeratins (CK18 and CK19) and human leukocyte antigen (HLA) class I proteins, display elevated levels of AKT activation and pro-survival Bcl-2 protein expression, and demonstrate a higher tumor-propagating capacity in vivo compared to their parental, docetaxel-sensitive cells [162]. This evidence concerns the gene AKT1 and neoplasm.