At least in a mouse model, luminal cell-derived prostate tumors seem to recapitulate the more aggressive types of human PCa [26], while NKX3.1 haploinsufficiency, PTEN loss and/or allelic gain of the c-MYC gene in human PCa are associated with increased biochemical relapse (recurrence of PSA serum levels) following radiotherapy [58, 59]. Here, PTEN is linked to posterior cortical atrophy.