PTEN ablation in prostate luminal cells is capable of driving PCa formation itself, as PTEN loss following PSA promoter-driven TAM-inducible Cre expression (PSACreERT2Ptenlox/lox) resulted in PIN formation (2-3 months) followed by invasive adenocarcinoma development (8-10 months) [56]. Here, PTEN is linked to posterior cortical atrophy.