More recently, Shen and colleagues demonstrated through genetic lineage-tracing that prostate luminal cells, but not prostate basal cells, were consistently observed as the PCa cell-of-origin in a diverse range of mouse models (Pten+/−, Nkx3.1+/−Pten+/−, TRAMP, and transgenic ARR2/probasin-driven Myc) in situ [57]. This evidence concerns the gene PTEN and posterior cortical atrophy.