Integrative analysis of mRNA expression, copy number and exon sequencing for somatic mutations conducted on a cohort of PCa patients revealed that the PI3K/AKT pathway was altered in 42% of primary cancers and 100% of metastases, while the RAS/MAPK pathway was altered in 43% of primary specimens and 90% of metastases [106]. The gene discussed is AKT1; the disease is posterior cortical atrophy.