SLC22A3 and Familial prostate cancer: Although overall the links between the “invasion and/or AIG” genes and prostate cancer or carcinogenesis in general are scarce, the association of decreased SLC22A3 levels and tumor aggressiveness was previously reported by two groups as part of both an “underexpressed in high Gleason grade signature” and an “underexpressed in progression signature” [55, 56].