While this oncogenic prostate-specific role of TMEFF2 is in line with our observed positive association between TMEFF2 and ETV1 and ETV4 expression, being significantly decreased with silencing of either ETS, our panel of PCa subtyped for ETS rearrangements [23] showed an association of TMEFF2 overexpression with non-PEA3-positive PCa. Here, TMEFF2 is linked to posterior cortical atrophy.