OTUD7B and familial cylindromatosis: It has been determined that many DUBs, such as cylindromatosis (turban tumour syndrome) (CYLD), A20, and OTU deubiquitinase 7B (OTUD7B), negatively regulate NF-ĸB signalling by ubiquitin deconjugation of key signalling molecules such as RIP1 [8].