Inparticular, MC3181 efficiently inhibited proliferation of both the amelanotic andBRAF-mutated A375 cells, and of the melanotic and BRAF wild-type SK23-MEL cell line.On the other hand, the drug disclosed a different ability in inducing apoptosis inthese two cell lines, suggesting a propensity for MC3181 to exert its antitumoractivity against BRAF-mutated melanoma cells. This evidence concerns the gene BRAF and melanoma.