As shown in Figure 2E, knockdown of G9a expression with shG9a2 most proficiently attenuated HT29 cell growth in nude mice in comparison to the shCon, shG9a1, and shG9a3 groups, with tumor volumes of 266 ± 102 mm3, 1678 ± 593 mm3, 701 ± 331 mm3, and 930 ± 194 mm3, respectively on the 32nd day. This evidence concerns the gene EHMT2 and neoplasm.