It has been more than 40 years since Judah Folkman published his classic article “Tumor angiogenesis: therapeutic implications” [2], and it is now well recognized that vascular endothelial growth factor (VEGF), which exerts its functions mainly by binding to both VEGF receptor 1 (VEGFR1) and VEGF receptor 2 (VEGFR2), is the master regulator of the process. The gene discussed is KDR; the disease is neoplasm.