To this aim, we performed luciferase assays in the papillary thyroid carcinoma cell line TPC-1, showing high activity levels of the SPP1 promoter (Supplementary Figure 1), transfected with a vector encoding the luciferase gene under the control of the SPP1 promoter and with single or both vectors encoding the HA-tagged CBX7 (CBX7-HA) or the HMGA1b-HA protein. Here, SPP1 is linked to differentiated thyroid carcinoma.