In conclusion, we demonstrated that PATZ1 exerts an oncosuppressor role in thyroid cancer, particularly in the progression to an anaplastic phenotype, through the regulation, at least in part, of p53-target genes EpCam, RhoE and Caldesmon, thus resulting in reduced migration and invasion in vitro, as well as MET and reduced tumor growth in vivo. Here, EPCAM is linked to thyroid cancer.