In conclusion, we demonstrated that PATZ1 exerts an oncosuppressor role in thyroid cancer, particularly in the progression to an anaplastic phenotype, through the regulation, at least in part, of p53-target genes EpCam, RhoE and Caldesmon, thus resulting in reduced migration and invasion in vitro, as well as MET and reduced tumor growth in vivo. The gene discussed is CALD1; the disease is thyroid cancer.