PATZ1 and thyroid cancer: Therefore, choosing the thyroid cancer cell lines TPC1, BC-PAP and FRO, as cellular models for undifferentiated tumors, we showed that in all of them reintroduction of PATZ1 leads to inhibition of cellular capacity to migrate and invade, supporting a role for PATZ1 in opposing the late steps of thyroid transformation, consisting in the acquisition of a mesenchymal phenotype (EMT), capable to migrate and invade surrounding tissues, thus giving rise to local and distal metastases.