However, this concept was called into question by studies suggesting that DHEA sulfation by the enzyme DHEA sulfotransferase, SULT2A1, is the predominant reaction, and the conversion back to DHEA through the enzyme steroid sulfatase is only a rare occurrence (1, 2), except for distinct tissues with ample steroid sulfatase activity, such as placenta and cancers of prostate, breast, endometrium, and colon (3). This evidence concerns the gene STS and Familial prostate cancer.