Two recent studies looked at the association of common genetic variants (minor allele frequency [MAF] > 5%) in SULT2A1 and PAPSS2 with androgen status (24, 25); future studies with a more detailed phenotyping and genotyping approach will need to investigate impaired DHEA sulfation as a predisposing factor to PCOS by looking for low frequency (MAF < 5%) and rare variants (MAF < 0.5%). Here, PAPSS2 is linked to polycystic ovary syndrome.