Additionally, LANA has also been shown to deregulate the expressions many oncogenes (by stabilizing) and tumor suppressors (by degrading) to induce tumor growth and these includes c-Myc, p53, hypoxia-inducible factor 1 (HIF-1), glycogen synthase kinase 3 (GSK3), von Hippel-Lindau protein (pVHL) and β-catenin [84,85,86,87,88,89]. Here, VHL is linked to neoplasm.