BRCA1 dysfunction as seen in sporadic SEOC could unleash Ubc9 resulting in down regulation of caveolin-1 expression causing loss of multiple physiological functions of caveolin-1 (like tumor suppression, DNA repair, lipid trafficking, cellular signaling, endothelial and mitochondrial function) resulting in tilting the balance towards ovarian cancer (Figure 4). Here, UBE2I is linked to ovarian cancer.