CNR2 and anemia (phenotype): As the cannabinoid receptor 2 is responsible for retention of immature B cells in the bone marrow [29] and leukemic cells in the bone marrow disrupt the normal hematopoiesis [30], we hypothesized that the anemia might be secondary to high bone marrow infiltration but morphological re-evaluation of staging bone marrow biopsies did not support this hypothesis (data not shown).