We normalized CNR1, CNR2 and FAAH expression to non-malignant B-cells from a single donor as described above and analyzed the expression levels in relation to clinical features (age, sex, anemia, thrombocytopenia, leukocytosis and lymphocytosis, LDH-levels, Ann Arbor stage, B-symptoms, splenomegaly, nodal presentation, mantle cell lymphoma international prognostic index (MIPI)), to overall survival (OS) and to pathological features (blastoid morphology, proliferation measured as Ki67-index, SOX11 positivity and p53 expression analyzed by IHC). The gene discussed is SOX11; the disease is Splenomegaly.