In the liver, the ov-serpin SERPINB3 (or SCCA1) and its isoforms SERPINB4 (or SCCA2) are undetectable in normal hepatocytes, but their expression progressively increases in chronic liver diseases, dysplastic nodules and HCC, suggesting that they may be involved in relatively early events of hepatocarcinogenesis, although their specific role has not been defined yet [5]. Here, SERPINB3 is linked to hepatocellular carcinoma.