TGFB1 and hepatocellular carcinoma: In the article “SERPINB3 is associated with TGF-β1 and cytoplasmic β-catenin expression in hepatocellular carcinomas with poor prognosis” [5] Turato et al, for the first time, provided evidence that in liver tumors the expression of the protease inhibitor SERPINB3 was correlated with the molecular markers of poor prognosis, (TGF-β signalling associated with Wnt target gene expression).