TREM2 has been strongly linked to AD and general dementia by several studies [40, 48-50], including the study by Lambert et al., which identified an AD susceptibility SNP (rs9381040; P = 6.3 × 10−7) only 24 kb away from the 5′ end of TREM2 [14]. The gene discussed is TREM2; the disease is Alzheimer disease.