PTK2B and Alzheimer disease: Work on two transgenic AD mouse models has shown that the VEGFR inhibitor sunitinib re-establishes proper expression levels of proteins involved in vascular integrity, such as Aβ, thrombin, tumor necrosis factor-α, interleukin-1β, interleukin-6, and matrix metalloproteinase 9; NEDD9 and PTK2B were unfortunately not evaluated in this study [158].