Compared to tumor tissues from animals that received no treatment or LOFU or 17AAG alone, immunoblot analysis demonstrated a significant increase in the expression of ERp78 (p<0.03, Figure 2D & E), ERp44 (p<0.05, Figure 2D & G), and ERp57 (p<0.04, Figure 2D & F) protein levels in tumor tissues following combination treatment with LOFU+17AAG. The gene discussed is PDIA3; the disease is neoplasm.