BRCA1 and breast cancer: Although far from the scope of our article, is important to note that Chen et al. have reported for the first time the aberrant localization of BRCA1 in breast cancer cells cytoplasm, pointing that the sub cellular localization of BRCA1 suggests that abnormalities in BRCA1 are fundamental in breast tumors, and could be caused by intragenic mutation, and so on, loss of function of BRCA1 [11].