NOP53 and neoplasm: Although further study will be required to address the significance of cytoplasmic PICT1 protein expression, together with results of this study, these predictions raise the possibility that PICT1 in the cytoplasm might also be important in tumor progression to control TP53 accumulation by regulating localization of ribosomal protein in the cytosolic ribosomal fraction, as well as nucleolar PICT1 to retain RPL11 in the nucleolas.