This study scrutinized the expression of PICT1 in the nucleoli and cytoplasm of NSCLC cells with wild-type TP53. PICT1 has been known to be a nucleolar protein; however, in our study many NSCLC tissues expressed PICT1 not only in the nucleoli but also in the cytoplasm. The gene discussed is NOP53; the disease is non-small cell lung carcinoma.