In fact, low PICT1 mRNA expression was associated with better prognosis in colorectal tumors, esophageal tumors, hepatocellular carcinomas and gastric cancers with wild-type TP53, therefore PICT1 was considered to be a useful prognostic marker for these cancers [4, 6, 7]. Here, NOP53 is linked to hepatocellular carcinoma.