The most recurrently deregulated SOX genes, arbitrarily defined here as having a minimum 20% frequency of deregulation in at least 9 of the 11 different cancer types, included underexpression of SOX2 (10/11), SOX5 (10/11), SOX6 (10/11), SOX7 (9/11), and SOX10 (11/11) and overexpression of SOX4 (10/11), SOX11 (9/11), and SOX12 (9/11) (Figure 1, Supplemental Table 1). The gene discussed is SOX12; the disease is cancer.