Anti-cancer correlations with improved patient prognosis have been based on findings of hypermethylation of the EFEMP1 gene [10-16], down-regulated EFEMP1 expression in cancer specimens and derived cancer cell line [10-12, 15-16], and positive correlations of EFEMP1 expression with suppressed lymph-node metastasis [14, 16] and overall survival [11-17]. This evidence concerns the gene EFEMP1 and cancer.