However, for gliomas, EGFR's prognostic value can only be properly interpreted in the context of EFEMP1. High EGFR expression is functionally mitigated by high EFEMP1 expression, whereas low EFEMP1 expression identifies the subset of glioma patients for whom anti-EGFR therapies might be the most beneficial. The gene discussed is EGFR; the disease is central nervous system cancer.