Interestingly, our data on exosomal protein profiles from treated Caco-2 showed an enrichment of upregulated proteins involved in tumor etiopathogenesis, including CRC (CD59, CRP, CTSD, HMMR, LY6K, TRIM22), and in cell cycle control (BRAF, CDC2, ERBB2). The gene discussed is HMMR; the disease is colorectal carcinoma.