Gastric cancer patients with high frequency of recurrence and poor survival outlook showed low levels of miR-142-5p [48]; in contrast, its expression is elevated in peripheral blood leukocytes from IL-10(−/−) mice during minimal colon inflammation [49]; inhibiting miR-142-5p in healthy donor CD4+ T-cells caused T-cell overactivation and B-cell hyperstimulation, whereas its overexpression in Systemic Lupus Erythematosus CD4+ T cells had the opposite effect [50]. Here, CD4 is linked to systemic lupus erythematosus.