TMPRSS2 and nonpapillary renal cell carcinoma: In the patient cohort, ATP6V0A4, KCNJ1, CLDN8, TMPRSS2 and KNG1 were significantly reduced, whereas NNMT, NR3C1, CAV1, ARHGDIB, NETO2 and ATP2B4 mRNA levels were significantly elevated in ccRCC (Figure 9).