Among the co-upregulated genes, CSF2RB, VEGFA, FLT1 and CSF1R participate in the Cytokine- cytokine receptor interaction pathway (adjP=0.0003); VWF, VEGFA and FLT1 are related to the Focal adhesion pathway (adjP=0.0018) and EGLN3 and VEGFA participate in the Renal cell carcinoma pathway (adjP=0.0020). The gene discussed is VEGFA; the disease is hereditary clear cell renal cell carcinoma.