In the patient cohort, ATP6V0A4, KCNJ1, CLDN8, TMPRSS2 and KNG1 were significantly reduced, whereas NNMT, NR3C1, CAV1, ARHGDIB, NETO2 and ATP2B4 mRNA levels were significantly elevated in ccRCC (Figure 9). The gene discussed is KNG1; the disease is nonpapillary renal cell carcinoma.