The mean vessel density as determined by the CD31 positivity was significantly decreased into the tumor surrounding stroma (Figure S7A, p=0.004-0.01) and the tumor beds (Figure S7B, p=0.001-0.009) of the MDA-9/Syntenin depleted FaDu and SCC-15 xenografts compared to their respective empty vector treated controls. The gene discussed is PECAM1; the disease is neoplasm.