MiR-128b is mapped on chromosome 3, within the 18th intron of ARPP21 gene [147] and a frequent loss of heterozygosity (LOH) [148] in NSCLC was discovered; EGFR is a direct target of miR-128b, so its reduced expression promotes carcinogenesis by the derepression of this oncogene [148]. This evidence concerns the gene ARPP21 and non-small cell lung carcinoma.