In a further study, Mei et al. found that snoRNA42 was overexpressed in NSCLC cells, and demonstrated that snoRNA42 knockdown decreased tumorigenicity in vitro and in vivo by inducing p53- mediated apoptosis, whereas its upregulation promoted the cell growth of bronchial epitheliums [273]. This evidence concerns the gene TP53 and non-small cell lung carcinoma.