HOTAIR and metastatic malignant neoplasm in the lymph nodes: This data was confirmed and expanded upon by Nakagawa et al., who, by examining the expression of HOTAIR in 77 NSCLCs and 6 brain metastases by quantitative real-time RT-PCR, showed that high levels of expression of HOTAIR were associated with advanced stages of disease, lymph node metastasis and a shorter disease-free interval.