A growing body of evidence suggests that miR-221/222 are involved in the resistance of NSCLC cells to TRAIL (Apo2L/TNFα-related apoptosis-inducing ligand) [74], and this hypothesis are further corroborated by the observation that NSCLC cells transfection with anti-miR-221/222 results in TRAIL sensitivity in NSCLC [74]. The gene discussed is TNFSF10; the disease is non-small cell lung carcinoma.