However, additional targets of miRNAs 221-222, such as PTEN/TIMP3 [75] and PUMA (also known as Bcl-2 binding component 3) [76], seem to mediate TRAIL resistance, migration and invasiveness, thus correlating with the frequent overexpression of these miRNAs in epithelial cancers, including lung cancers [78]. This evidence concerns the gene BBC3 and lung cancer.