The proliferation of various human cancers in vitro is suppressed by GHRH antagonists.[41] A report suggests that the dysregulation of GHRH expression or autocrine/ paracrine secretion contributes to the pathogenesis of breast and other cancers.[42] In vivo investiagtions have demonstrated the anti-tumor activity of GHRH antagonists against multiple cancer types. Here, GHRH is linked to neoplasm.