GHRH and cancer: [17-28] Much evidence indicates that GHRH acts as an autocrine/paracrine growth factor in many human cancers [6, 23, 29-31] including that of the breast.[32] Pituitary-type GHRH-R and splice variant 1 of GHRH-R appear to mediate the direct effects of GHRH and its analogs on tumors.[33] In vitro and in vivo proliferation of various human cancers is suppressed by antagonistic analogs of GHRH (referred to as “GHRH antagonists”).[8, 34, 35] These findings support the concept of GHRH as a growth factor for tumors and suggest that GHRH-R could be used as a suitable therapeutic target.