GHRH and breast carcinoma: We have recently reported that the GHRH antagonist, MIA-602, suppresses the expression of inflammatory cytokines in human TNBC tumors xenografted into nude mice.[36] Cytokines have been shown to play a major role in the cellular signaling involved in the pathogenesis of breast cancer.[37-39] In this study, we used HCC1806 and doxorubicin-resistant MX-1 human TNBC cell lines xenografted into nude mice to evaluate the effects of a GHRH antagonist (MIA-602) alone and in combination with doxorubicin.