Edelfosine has been found to promote apoptosis in a wide number of cancer cells through the involvement of Fas/CD95 death receptor [20, 22, 23, 53, 54], but the results reported here suggest that U118 glioma cells have some molecular features that make them prone to undergo this necroptotic cell death instead of apoptosis upon edelfosine incubation. The gene discussed is FAS; the disease is glioma.