FADD and hematopoietic and lymphoid cell neoplasm: Edelfosine has been reported to induce apoptosis in a variety of hematological cancer cells through the recruitment into lipid rafts of extrinsic apoptotic pathway molecules forming clusters of Fas/CD95 death receptor and downstream signaling molecules, including FADD and procaspase-8 [22, 23, 28, 42, 43].