FAS and central nervous system cancer: Edelfosine has been found to promote apoptosis in a wide number of cancer cells through the involvement of Fas/CD95 death receptor [20, 22, 23, 53, 54], but the results reported here suggest that U118 glioma cells have some molecular features that make them prone to undergo this necroptotic cell death instead of apoptosis upon edelfosine incubation.