KLF9 and cancer: Next to loss of expression in 6 out of 16 cancer types (Supplementary figure 3A), KLF9 was shown to be significantly downregulated in breast carcinoma when compared to normal breast epithelium, applying P ≤ 0.01 and fold change ≥ 2 as thresholds (Supplementary figure 3B-D, Supplementary table S4 ) ([14, 15] and TCGA Research Network).