GRP78 expression has been reported to be increased in a number of human cancers, including breast (19, 20), lung (21, 22), prostate (23, 24), ovarian (25), gastric (26), hepatocellular (27, 28), esophageal (29), renal (30), endometrial (31, 32), melanoma (33), glioma (34), and fibrosarcoma (35) (Table 1). Here, HSPA5 is linked to melanoma.