The role that pro-inflammatory cytokines play in obesity, i.e., TNF-α, IL-6, IL-1, and leptin (23) and the concomitant decrease in the pro-inflammatory cytokine, adiponectin (24) may play in esophageal contractility and increased incidence of esophagitis is unclear as is their role in gastric motility, gastritis, small and large bowel function in obesity. This evidence concerns the gene TNF and Obesity.