In the case of rs4796793 and the effect of IFNα in renal cell carcinoma, it is assumed to be a direct effect, since the authors reported a small (R2 = 0.14) but significant correlation between rs4796793 and STAT3 mRNA expression in Epstein–Barr virus transformed B-lymphocyte cell lines, i.e., a higher expression in cells being homozygote for the major allele (7). Here, STAT3 is linked to hereditary clear cell renal cell carcinoma.