While most cutaneous melanomas harbor a BRAF or NRAS mutation (see Table 1), CCS in approximately 75% have a t(12;22)(a13;q12) or less commonly a t(2;22)(q34;q12) translocation leading to the EWSR1/ATF1 or EWSR1/CREB1 fusion transcripts (53, 54). Here, CREB1 is linked to cutaneous melanoma.