A 36-year-old woman with a history of a superficial spreading melanoma of the back 16 years earlier, presented with a large lung mass, which was thought to be a non-small cell lesion, probably squamous cell carcinoma based on fine needle aspiration (EUS-FNA); melanoma markers HMB45 and MART were negative, while the squamous cell marker – p63 – was weakly positive. The gene discussed is SEPTIN4; the disease is squamous cell carcinoma.