PPFIBP1 and ITGA6 also have roles in cell adhesion (48, 49), and the PPHLN1 protein is found at cell-cell junctions and is thought to have a role in barrier formation (50), highlighting the possibility that this aspect of endothelial cell biology plays a role in the pathogenesis of FECD. Here, ITGA6 is linked to Fuchs endothelial corneal dystrophy.