Analysis of pancreata harvested from KC and AKC mice at different ages revealed the presence of occasional ATDC-expressing cells in KC mice even in early PanIN lesions, with a gradual increase in the numbers of ATDC-expressing cells as PanIN lesions progressed to invasive carcinomas (Fig. 2E; Supplemental Fig. 4A,B). This evidence concerns the gene TRIM29 and keratoconus.