Quantitative RT–PCR (qRT–PCR) analysis of harvested pancreata from 3-, 6-, and 8-mo-old KC and AKC mice confirmed a gradual increase in ATDC expression during PanIN–PDA progression, albeit at levels lower than those observed in AKC mice (Supplemental Fig. 4B). The gene discussed is TRIM29; the disease is Patent ductus arteriosus.