CD4 and neoplasm: To determine the importance of TLR7 expression in DCs in Loxoribin-triggered antitumor immunity in vivo, we purified CD4+CD8−T cells, CD4−CD8+T cells and CD4+CD25+Treg cells, and mixed them with Loxoribin-treated or non-treated DCs from wild type mice as indicated, and then injected them into tumor cell bearing mice.