For instance, in a randomized global phase III study, onartuzumab mAb (MetMAb), which is directed against c-MET receptor, is currently investigated in combination with 5-fluorouracil, folinic acid, and oxaliplatin (mFOLFOX6) in patients with metastatic HER2-negative and MET-positive gastric and GEJ adenocarcinoma (NCT01662869). This evidence concerns the gene ERBB2 and gastroesophageal junction adenocarcinoma.