In a mouse model, inhibition of FAPα with PT-100 resulted in an antitumor effect implicating tumor-specific cytotoxic T lymphocytes, protection of immunological memory, augmented antitumor activity of antibody-increasing cytokines [interleukin (IL)-1, IL-6, interferon, granulocyte-colony stimulating factor] and chemokines (76). This evidence concerns the gene FAP and neoplasm.