The human breast cancer cell lines MDA-MB-435 and MDA-MB-436, stably transfected with anti-sense oligonucleotides of FAPα, demonstrated slower proliferation than their FAPα-expressing counterparts in serum-free medium but not in serum-containing medium, indicating that breast cancer cells with high FAPα expression levels may be independent from exogenous serum factors for growth (72). The gene discussed is FAP; the disease is breast cancer.