MGAT3 and Alzheimer disease: We have previously found that the glycosyltransferase, GnT-III (encoded by the MGAT3 gene) (Nishikawa et al, 1992), which is the sole biosynthetic enzyme for bisecting GlcNAc modification (Bhattacharyya et al, 2002), is upregulated in the brains of AD patients (Akasaka-Manya et al, 2010), but how this increase in bisected glycan contributes to AD pathology remained unclear.