Further, K1 induces B-cell lymphomas in transgenic mice through constitutive Lyn kinase activation, crucial for the production of VEGF and NF-kB activation [64,65], and induces MMP-9 and VEGF secretion from epithelial and endothelial cell lines [30,31]. This evidence concerns the gene MMP9 and B-cell non-Hodgkin lymphoma.