The DV-induced cytokine storm could enhance the effects of a variety of cancer immunotherapy approaches as follows: (1) direct targeting of the tumor cells, (2) targeting tumors in synergy with hyperthermia (TNFα), (3) expanding anti-tumor effector CTL, or (4) inducing tumor-reactive LAK or CIK cells, and (5) overcoming many of the immune evasion mechanisms employed by the tumor cells (Table 2) [43,66]. This evidence concerns the gene TNF and cancer.