The validation data set showed similar effect sizes and association levels of S100A2 with disease prognosis [HR = 1.40 (95% CI = 1.04, 1.90), p = 0.03, Table 3] confirming the applicability of cytoplasmic S100A2 % positivity as a prognostic factor for cancer recurrence/death. Here, S100A2 is linked to cancer.