Furthermore, an increase in apoptotic astrocytes was observed in AppTg/Cebpd−/− mice [an Alzheimer disease mouse model (APPswe/PS1/E9 bigenic) crossed with Cebpd-deficient mice], thereby suggesting that CEBPD plays a functional role in contributing to the anti-apoptotic ability of astrocytes [69]. Here, CEBPD is linked to early-onset autosomal dominant Alzheimer disease.