A previous study has shown that different growth factors or their receptors or transcription factors (e.g., AP-1, NF-κB, and β-catenin) can upregulate the expression of cyclin D1/E proteins and cyclin D1 protein stability/nuclear accumulation in oral squamous cell carcinoma (25). The gene discussed is NFKB1; the disease is oral cavity squamous cell carcinoma.