ORMDL3 and asthma: The SNPs discovered by GWAS that are associated with asthma are also associated with the expression of both GSDMB and its close neighbour ORMDL3 in white blood cells12, peripheral blood mononuclear cells21, lymphoblastic cells lines42, CD4+ T cells23, 24 and lung tissue22, and it has been assumed both that the causal SNPs at this locus are expression quantitative trait loci for these genes and that one or both of these genes are involved in asthma pathogenesis.