Mechanistically, we found that CBD inhibits the expression of Sox2, Id1, p-STAT3 and upregulates phosphorylated (p)-p38 MAPK, all of which have been connected to inhibition of self-renewal and stemness in GBM.16 Importantly, these effects were also dependent on ROS production, as demonstrated by partial or complete reversal induced by cotreatment with VitE (Figure 3c). Here, SOX2 is linked to glioblastoma.