STAT3 and glioblastoma: Mechanistically, we found that CBD inhibits the expression of Sox2, Id1, p-STAT3 and upregulates phosphorylated (p)-p38 MAPK, all of which have been connected to inhibition of self-renewal and stemness in GBM.16 Importantly, these effects were also dependent on ROS production, as demonstrated by partial or complete reversal induced by cotreatment with VitE (Figure 3c).