One of the major systems used by both normal and cancerous cells to counteract oxidative insult is the NRF2 (also known as NFE2L2) transcriptionally regulated program.9 The role of NRF2 transcriptional regulator and SLC7A11 (solute carrier family 7 (anionic amino-acid transporter light chain), member 11) in mediating GBM response and resistance to redox-directed therapeutics has not been evaluated. Here, NFE2L2 is linked to glioblastoma.