Upon sensing of increase ROS levels, NRF2 is released from its complex with KEAP1, and it translocates to the nucleus, where it binds ARE found in the promoters of ROS-detoxifying enzymes, including NQO1, GST, HMOX-1 and xCT.18, 31 Importantly, augmented expression of both NRF2 and xCT was observed in vivo in CBD-treated tumor tissue, as compared with vehicle. This evidence concerns the gene NFE2L2 and neoplasm.