HIF-1α induction in kidney and liver was shown to be transient; however, HIF-2α expression is sustained.11 Moreover, HIF-1α was transiently stabilized and primarily mediated acute responses, whereas HIF-2α gradually accumulated and managed prolonged hypoxic gene activation under hypoxia (1% O2) in neuroblastoma. Here, EPAS1 is linked to neuroblastoma.