NQO1 and Patent ductus arteriosus: As Dic is an NADH mimic and may have off-target effects, we developed genetically matched NQO1+ and NQO1− PDA cells from parental NQO1 polymorphic NQO1- S2-013 cells as described.30 Note that ATP depletion caused by FK866 alone was not dependent on NQO1 expression, whereas β-lap-induced cytotoxicity and synergy only occurred in NQO1+, and not in NQO1-, S2-013 cells (Figure 2b) (P=0.00012).