PKR phosphorylation is known to have a significant role in AD,13 and cerebrospinal fluid (CSF) PKR levels could be used as a potential diagnostic biomarker in AD patients.14, 15 PKR is a proapoptotic kinase16 and can exert a number of toxic effects on neurons that could contribute to the functional and pathological alterations in AD brains. Here, EIF2AK2 is linked to Alzheimer disease.