Previous studies have shown that PKR-induced eIF2α phosphorylation could increase BACE1 translation.18, 19 To evaluate the functional importance of the PKR-eIF2α pathway in amyloidogenic signaling in TD mice, APP processing was assessed by immunoblotting of APP, BACE1 mature form and amyloid oligomers (Figure 7a). This evidence concerns the gene EIF2A and thanatophoric dysplasia.