EIF2AK2 and thanatophoric dysplasia: Previous studies have shown that PKR-induced eIF2α phosphorylation could increase BACE1 translation.18, 19 To evaluate the functional importance of the PKR-eIF2α pathway in amyloidogenic signaling in TD mice, APP processing was assessed by immunoblotting of APP, BACE1 mature form and amyloid oligomers (Figure 7a).