The expression of activated PKR in the cerebellum is mainly in the Purkinje layer that is partly comparable to the findings described by our group in the human brain affected by prion diseases that can trigger PKR activation.32 This expression pattern is also in line with the PKR mRNA profile visible on the Allen Brain Atlas, which shows a strong expression in Purkinje cells. The gene discussed is EIF2AK2; the disease is prion disease.